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To add something constructive:

I've used a novel nootropic which is an adenosine antagonist (KW-6356) for long-lasting energy without dopaminergic stimulation. Something I found and which is commonly reported by other users is mood-enhancing properties:

https://en.wikipedia.org/wiki/Sipagladenant



How do you know that's not frying some kind of receptor in your body? It seems there are no free lunches with antagonist drugs


  > How do you know that's not frying some kind of receptor in your body?
I don't. One of the things I enjoy about life is being able to experiment on my own body.


The manufacturer doesn't make it clear why they axed it, but from my experience in med-tech I think this translates to "the FDA is going to balk at it"

https://www.kyowakirin.com/media_center/news_releases/2022/p...




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