I want my offline client to have a plugin system like Anki. Powerful plugins will want to manipulate the DOM directly. They can't do this if I'm using a virtual DOM, which is what Blazor uses. (VDOM updates will overwrite any plugin DOM changes.) There are Fable bindings to React, but of course that also uses a VDOM.

I can't express in words how seriously sad I am to leave F# for the shitshow that is TypeScript. I tried to make ReScript work, but it's tightly coupled to React for baffling reasons.