With the big, big, notable exception: targeting the browser.

To be perfectly fair, unless you count WASM or other compiles-to-JS-but-not-quite-native langs (which, outside TS, are pretty niche), this is the case with literally every language except JS.

> unless you count WASM or other compiles-to-JS-but-not-quite-native langs

As a happy user of clojurescript, or seeing the popularity and adoption rate of typescript, I do not count them out.

Not counting them out either, but outside TS, they're still quite marginal, at best.

JavaScript and it’s variants are 1st place for the browser (shoe in on a technicality) ... but like 213th for everything else.

Possibly not for long: https://www.brython.info/

Brython has been around since 2014.