I'll have to disagree. Having worked at a "large established company" during my career, I'd say that I've been given the chance to experiment with plenty of new things and projects are also started more often than you'd think, even though not all of them make it to a release. I understand your point, that just because you've worked at a large company it doesn't mean you have the right skills for a startup, however I will still hold my point: it highly depends and I wouldn't discard the opposite situation.
I’ve never worked in a large company where I would be doing everything from front end, middle tier, databases, CI/CD design, creating cloud networking infrastructure, dealing with vendors, designing operations, and talking with customers in the course of a month. This was me last month. Admittedly front end design is a major weakness of mine even though I do know JS well.
